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D-aspartic acid, also known as DAA is a popular name in the sports supplement market. It has a unique metabolic pathway that helps convert it to N-methyl-D-Aspartate under the influence of some receptors.

DAA increases the levels of gonadotropin, luteinizing hormone, and follicle-stimulating hormone. It also increases the levels of testosterone and so promotes the growth of muscles and strength. But this may also cause you to lose some important brain cells. 

DAA could kill NMDA receptors in the brain. These receptors are responsible for helping humans appropriately and simultaneously adapt to various changes in their environment. When you lose these receptors, it may increase your risk for some conditions like Alzheimer’s and other central nervous system diseases.


What Exactly is D-aspartic Acid?

D-aspartic acid, also called D-asparagine or D-aspartate is a nutritional supplement well known for boosting testosterone levels. It is not only an amino acid but also a spatial isomer of L-asparagine.

The D-form of DAA is usually metabolized in the N-methyl-D-aspartate, which is a substance known for stimulating NMDA receptors in the brain. These receptors are related to the memory capabilities of the brain just as they are to the plasticity of brain synapses.

What is it used for?

D-aspartate functions as neuro-modulators and neurotransmitters. They stimulate the synthesis of enzyme proteins in the nerve cells. They also regulate hormonal levels when in the endocrine system. There, they also increase the levels of gonadotropin, luteinizing hormone, and follicle-stimulating hormone.

Health Benefits

D-aspartic acid has been shown to have the following health benefits:

  •  It boosts the synthesis of testosterone and luteinizing hormone
  • Due to increased synthesis of testosterone, it hence boosts the synthesis of aromatase, a key enzyme in estrogen biosynthesis
  •  It can help boost prolactin synthesis
  •   It is effective for increasing the levels of gonadotropin-releasing hormone and growth hormone in rodents
  •   Effective in increasing progesterone production
  •   It stimulates the release of Gamma-aminobutyric acid (GABA), which are biogenic amino acids synthesized in the brain to boost concentration and mental calmness. GABA deficiency can cause cramps and convulsions.
  •         Research also shows that it can permanently increase the levels of testosterone.


How Does D-aspartate Work?

D-aspartate promotes two secondary signaling proteins: cGMP and cAMP. The cAMP is produced in the Leydig cells, acting as a boost for the synthesis of sex hormone, including progesterone and testosterone. cGMP, on the other hand, enhances the activation of intracellular protein kinases which hence result in increased production of prolactin, luteinizing hormone, and growth hormone.

In the hypothalamus, D-aspartate enhances the production Gonadotropin-releasing hormone (GnRH) which is actively involved in the secretion of luteinizing hormone and follicle-stimulating hormone from the anterior pituitary.

GnRH stimulates the release of vasopressin and oxytocin and induces the synthesis of matric RNA. 

What Are The Possible Side Effects?

D-aspartate often causes over-stimulation of NMDA receptors and so can be exotoxins working the same way as aspartame (E951) and monosodium glutamate (MSG). Whenever there is overstimulation, it causes the death of the affected receptor nerve cells.

Therefore, individuals that have hereditary risk of developing neurodegenerative diseases should not take exotoxins. 

What Is The Recommended Dosage And How Should It Be Taken?

10ml sodium D-aspartate (3.12g/10ml) is the only scientifically recommended dose for humans. And the supplement should be taken with vitamins B6, B12, and folic acid for 12 days.

D-aspartic acid could cause serious damage to the body when a higher dose is taken or when not taken with the vitamins. It increases the chance of having destroyed NMDA cells as well significantly increase the risk of developing various diseases.

However, it is very important that you don’t take it longer than the indicated period.

Who Should Not Use D-Aspartic Acid?

Pregnant women, breastfeeding women,and newborn babies should not receive D-aspartic Acid. The risk of exotocity also increases as the amount of intake also increases. So also as the age of the recipient.

People with a predisposition to neurodegenerative disease should also avoid taking D-aspartic Acid.

In Which Sports Supplements Is D-Aspartic Acid Common?

D-aspartic Acid is common in most testosterone and libido stimulants, as well as infertility supplements. It is usually in combination with aromatase inhibitors, B-vitamin, and other testosterone-stimulating agents.

It can also be found in some products on the market, including hormonal stimulants and in combination with energy (creatine) and nitric oxide precursors.

However, you need to remember that none of these products will ever write the dangerous exotoxic side effects on the packages. So since you are already aware of them, the decision is yours to make; whether to use them or not.

Bottom Line

D-aspartic Acid is a testosterone booster that has received some popularity in the supplement market. While some research has proven its amazing effectiveness, studies on human are very few. This makes them a bit more dangerous than other testosterone boosters that have received huge amount of clinical studies proving they are well-tolerated by human.

Now that you know its benefits and side effects, the choice is yours if you should use it or not. However, if you decide to use it, ensure you consult with your doctor beforehand. 

What Are The Possible Side Effects?

A potential adverse effect of piperine, which is the active compound in Bioperine, is that enhances the absorption of drugs beyond the required level, and so reduces the metabolic activities of the liver. However, this varies for different individuals. So, it’s important you speak with your doctor so he can recommend the right dosage of the supplement. Not using the right dosage can also result in the following side effects:

  •         Nausea
  •         Diarrhea
  •         Stooling (black)
  •         Constipation
  •         Bronchospasms
  •         Skin rash
  •         Anaphylaxis
  •         Itching
  •         Swelling of the skin
  •         Redness of the skin
  •         Hives
  •         Sleep disorder
  •         Depression
  •         Over-excitement


Interactions with Other Substances

Some medications have moderate to severe interaction with Bio-perine and so speak to your doctor if you are on any medication before you use Bioperine. Some of such drugs include:

  •         Ascorbic acid/Bortezomib/Deferoxamine
  •         Folic acid/Hydantoins/Pyrimethamine
  •         Pyridoxine/Altretamine/Levodopa


What Is The Right Dosage?

The dosage recommendation for the supplement varies and so should be taken as prescribed by your physician. However, the common dose is about 5-10mg per serve daily. Bioperine effects can be felt about 15 minutes on a short term and about 3 hours on a long term after consumption. 

Bioperine supplement has been a really active supplement when it comes to enhancing the bioavailability of other medication and food nutrients. That is the reason it is referred to as a bio enhancer. For years, and in many cases, it has proven that name. However, when taking Bioperine, it is advisable you speak with your doctor for the right dosage in order to avoid some side effects associated with the supplement. 

Table Of Contents

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Chapter 1 – What Exactly is D-aspartic Acid?

Chapter 2 – Health Benefits Of D-aspartic Acid


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